Novel Glycyrrhizinic Acid Derivative <scp>YCY</scp> ‐20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the <scp>AGE</scp> ‐ <scp>RAGE</scp> / <scp>MAPK</scp> Pathway
YCY-20 confers protection against CIRI, at least partially through apoptosis inhibition mediated by AGE-RAGE/MAPK signaling pathway modulation. This study provides preclinical evidence for developing licorice-derived agents in stroke management.
Authors
- Xue Qin (ORCID: https://orcid.org/0000-0002-3923-458X)
- Jiaxin Chen (ORCID: https://orcid.org/0000-0002-3507-6991)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Xinhui Pan
- Xiushi Yu
- Ziyun Liu
- Jia Luo
- Lili Wei
- Jiyi Lv
Institutions
- Shihezi University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70792
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00