p16 and <scp>MGMT</scp> Methylation in Chronic Traumatic Ulcers: A Plausible Link Between Chronic Mechanical Irritation and Oral Carcinogenesis?
Oral mucosa subjected to continuous exposure to CMI is associated with increased methylation of p16 and MGMT. Proper management of mechanical injury factors could be an important measure for OSCC prevention. In CMI, exfoliative cytology and the split-mouth design could be useful tools to study biomarkers. However, the role of CMI in oral carcinogenesis needs more evidence focusing on the biological phenomenon.
Authors
- Jerónimo Lazos (ORCID: https://orcid.org/0000-0002-0881-9614)
- Ana María Zárate (ORCID: https://orcid.org/0000-0002-3803-1430)
- Eduardo Piemonte (ORCID: https://orcid.org/0000-0001-5955-1139)
- Marcela Hernández Ríos
- Jessica Astorga
- Rene Luis Panico
Institutions
- Universidad Nacional de Córdoba (AR)
- University of Chile (CL)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1111/jop.70128
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00