The value of peripheral blood PLR, Lp-PLA2, MHR, SII, and HCY in assessing the rupture risk of small and medium-sized intracranial aneurysms

PLR, Lp-PLA2, MHR, SII, and HCY were associated with rupture status in small to medium-sized intracranial aneurysms. A combined multi-biomarker nomogram showed strong apparent discrimination; however, the incremental value beyond established clinical and morphological predictors and the generalizability of this model need confirmation in larger, preferably multicenter cohorts.