Mechanisms underlying the role of TNF-α and IL-1β preconditioned exosomes derived from human umbilical cord mesenchymal stem cells in wound healing
TNF-α+IL-1β-Exos demonstrated superior wound healing efficacy compared to Con-Exos. This enhanced therapeutic effect may be attributed to the elevated expression of miR-215-5p in TNF-α+IL-1β-Exos. Mechanistically, miR-215-5p activates the <i>WNK1</i>/<i>p-Smad3</i>/<i>VEGF-A</i> signaling axis, promoting angiogenesis and accelerating cutaneous wound repair.
Authors
- Wu Jin (ORCID: https://orcid.org/0000-0002-9492-4751)
- Ziyue Zhou
- Rui Cao
- Lei Shi
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1713004
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China