Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the <i>PICALM_EED</i> locus for Alzheimer’s disease
The <i>PICALM</i> gene is the primary driver of the association in microglia along with the CREe locus. Different SNPs in a segregating haplotype can display different physical Hi-C interactions. This study demonstrates that eHiCA can help resolve the casual genes driving complex GWAS associations, opening new pathways to study Alzheimer disease and other disorders.
Authors
- Leina Lu
- Wanying Xu (ORCID: https://orcid.org/0009-0000-3262-2013)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- W. Norman Scott (ORCID: https://orcid.org/0000-0002-1051-9952)
- Luciana Bertholim Nasciben
- Sofia Moura
- Xiaoxiao Liu
- Theresa Schuck
- Karen Nuytemans
- Farid Rajabli
- Katrina Celis
- Derek Dykxhoorn
- Sandra Weintraub
- Anthony Griswold
- Jeffery M Vance
- Marla Gearing
- Juan Young
- David Bennett
- Fulai Jin
- Margaret A PERICAK-VANCE
- Changiz Geula
Institutions
- Northwestern University (US)
- University of Miami (US)
- Emory University (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- Rush University (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-17
- DOI
- https://doi.org/10.64898/2026.02.14.705927
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Miami
- Hussman Foundation
- Leonard M. Miller School of Medicine