Modular Access to Nitriles From Carbonyls via Deoxygenative Transformation With Polarity Inversion
The C─O bond cleavage has always been a central challenge for deoxygenation due to high bond dissociation energies. Here, we develop a Lewis acid-promoted polarity inversion strategy that enables a strong C─O bond cleavage and rapid access to nitriles from carbonyls. Its broad applicability, together with the nontoxic and mild conditions, underscores the highly modular nature of this method.
Authors
- Wenying Xu (ORCID: https://orcid.org/0000-0002-5043-9148)
- Xia Ss
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- Yuanqiang Chen
- Tao XU
- Fancong Meng
Institutions
- Tongji University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1002/anie.8039232
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00