Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA
We uncovered a two-factor synergistic effect of a high-fat/choline diet on TMA/TMAO, and for the first time identified the genus <i>Serratia</i> as a TMA-producing bacterium. These findings provide a new potential target for intervening in metabolic disorders mediated by high-fat diet-induced TMAO elevation.
Authors
- Chang Li (ORCID: https://orcid.org/0000-0002-3267-1859)
- Lisi Tao
- Lizhong Hu (ORCID: https://orcid.org/0009-0006-8599-9678)
- Xiong Liu (ORCID: https://orcid.org/0000-0003-2939-574X)
- Jiaying Wei
- S. Li
- Zhuo Wang
- Zhengfeng Fang
- Ran Li
- Hong Chen
Institutions
- Sichuan Agricultural University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3390/nu18040658
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00