Clonal Dynamics and Molecular Heterogeneity of Metaplastic Breast Cancer: Focus on TP53 and PIK3CA Truncal Mutations

This study delineates the distinct mutational landscape and clonal evolution patterns of MBC, underpinned by truncal mutations in <i>TP53</i> and <i>PIK3CA</i> alongside dynamic <i>MCL1</i> amplification. The persistent activation of the PI3K-Akt pathway presents a key therapeutic vulnerability. Our findings emphasize the potential of PI3K-Akt inhibition and metastasis-specific targeting strategies for this aggressive disease.