Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation
Our data indicate that Smad7 overexpression in IECs is sufficient to promote ileal mucosal damage, which is linked to the impairment of purine metabolism.
Authors
- Ivan Monteleone (ORCID: https://orcid.org/0000-0002-3212-832X)
- Federica Laudisi (ORCID: https://orcid.org/0000-0001-7380-0269)
- Valentina Nola (ORCID: https://orcid.org/0000-0002-9259-0444)
- Teresa Pacifico (ORCID: https://orcid.org/0000-0002-5755-3672)
- Gustavo Monasterio (ORCID: https://orcid.org/0000-0001-6336-132X)
- Carmine Stolfi (ORCID: https://orcid.org/0000-0002-6354-2443)
- Francesca Zorzi
- Angela Ortenzi
- Eduardo Sommella (ORCID: https://orcid.org/0000-0001-8654-6431)
- Lorenzo Tomassini
- Massimo Claudio Fantini
- Eduardo Javier Villablanca
- Mattia Alberto Serra
- Cristiano De Stefanis
- Ombretta Melaiu
- Ning He
- Giovanni Monteleone
Institutions
- University of Rome Tor Vergata (IT)
- University of Salerno (IT)
- Karolinska University Hospital (SE)
- University of Cagliari (IT)
- Bambino Gesù Children's Hospital (IT)
- Policlinico Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1186/s12929-026-01224-3
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00