Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking
This study provides a theoretical framework for exploring the molecular mechanisms through which DEP may contribute to CRC development, emphasizing the value of network toxicology in cancer research. These findings may inform future investigations into the risks of DEP exposure and support public health policy and the development of targeted therapeutic strategies.
Authors
- Hengyi Lv
- Zijing Wang
- Liyuan Ma
- Zhanyuan Sun
- Mengqi Ding
- Tao Jiang
- Ruxue Ma
- Hai Li
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1371/journal.pone.0343038
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00