Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking

This study provides a theoretical framework for exploring the molecular mechanisms through which DEP may contribute to CRC development, emphasizing the value of network toxicology in cancer research. These findings may inform future investigations into the risks of DEP exposure and support public health policy and the development of targeted therapeutic strategies.

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Publication Details

Journal
PLoS ONE
Published
2026-02-17
DOI
https://doi.org/10.1371/journal.pone.0343038
Primary Topic
Effects and risks of endocrine disrupting chemicals
Type
article
Field-Weighted Citation Impact
0.00
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article

Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking

Hengyi Lv, Zijing Wang, Liyuan Ma, Zhanyuan Sun et al.
PLoS ONE
Effects and risks of endocrine disrupting chemicals
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Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking

Hengyi Lv, Zijing Wang, Liyuan Ma, Zhanyuan Sun, Mengqi Ding, Tao Jiang, Ruxue Ma, Hai Li
article en

Abstract

This study provides a theoretical framework for exploring the molecular mechanisms through which DEP may contribute to CRC development, emphasizing the value of network toxicology in cancer research. These findings may inform future investigations into the risks of DEP exposure and support public health policy and the development of targeted therapeutic strategies.

PLoS ONEVol. 21(2)
Gansu University of Traditional Chinese Medicine (CN), Ningxia Medical University (CN), Ningxia Medical University General Hospital (CN)
Good health and well-being
Openalex Percentile: Top 56%
Effects and risks of endocrine disrupting chemicals
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