Acute intraventricular hemorrhage triggered by coughing following return from high altitude: a case report and literature review

This case indicates that even brief stays at moderately high altitude may impair cerebrovascular self-regulation and increase stress on blood vessel walls. The resulting instability in blood flow during re-adaptation to lower elevation, combined with a sudden rise in intracranial pressure from a Valsalva-type action such as coughing, could lead to the rupture of susceptible vessels. Medical practitioners should consider this possible cause in cases of neurological emergency where there is a recent history of high-altitude exposure.

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Publication Details

Journal
Frontiers in Neuroscience
Published
2026-02-17
DOI
https://doi.org/10.3389/fnins.2026.1743120
Primary Topic
High Altitude and Hypoxia
Type
article
Field-Weighted Citation Impact
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article

Acute intraventricular hemorrhage triggered by coughing following return from high altitude: a case report and literature review

Wei Liu, Junfeng Li, Yangyang Gao, Lei Luo et al.
Frontiers in Neuroscience
High Altitude and Hypoxia
article

Acute intraventricular hemorrhage triggered by coughing following return from high altitude: a case report and literature review

Wei Liu, Junfeng Li, Yangyang Gao, Lei Luo, Zehong Zhang, Pengpeng Li
article en

Abstract

This case indicates that even brief stays at moderately high altitude may impair cerebrovascular self-regulation and increase stress on blood vessel walls. The resulting instability in blood flow during re-adaptation to lower elevation, combined with a sudden rise in intracranial pressure from a Valsalva-type action such as coughing, could lead to the rupture of susceptible vessels. Medical practitioners should consider this possible cause in cases of neurological emergency where there is a recent history of high-altitude exposure.

Frontiers in NeuroscienceVol. 20
Northwest University (CN)
Good health and well-being
Openalex Percentile: Top 51%
High Altitude and Hypoxia
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