Impact of fetal and maternal genetically predicted birth weight on cardiometabolic risk: a Mendelian randomization study of cytokine mediation in Europeans
This study provides evidence that both fetal and maternal genetically predicted BW independently influence cardiometabolic outcomes, with fetal genetic effects having a broader impact. Although inflammatory cytokines (PDGF-BB, MIP-1β, SDF-1α, IL-4) partially explain these effects, their contributions are limited, suggesting additional biological pathways underlie these lifelong associations.
Authors
- Runju Zhang
- Aixia Liu (ORCID: https://orcid.org/0000-0002-8115-8234)
- Hangying Lou
- Yonghui Jiao
- Yimin Zhu
- Hefeng Huang
- Ningning Hou
Institutions
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Ministry of Education (TH)
- Institute of Genetics (HU)
Publication Details
- Journal
- The Journal of Maternal-Fetal & Neonatal Medicine
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1080/14767058.2026.2629082
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00