Analysis of genetic polymorphisms in sudden sensorineural hearing loss and artificial intelligence-supported individualized precision therapy

In SSNHL treatment, the combined approach of postauricular subperiosteal and intratympanic steroid injections was significantly more effective than systemic steroid therapy, representing the optimal treatment choice. Specific genetic polymorphisms were closely associated with treatment response and may serve as molecular biomarkers for personalized therapy. The deep learning CNN model exhibited superior performance in efficacy prediction, surpassing conventional models, and could assist in precision treatment decision-making.