Evocalcet improved the PTH–calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism
Evocalcet, similar to cinacalcet, lowers the PTH-calcium setpoint and inhibits parathyroid cell proliferation in a mouse model of primary hyperparathyroidism. These findings suggest that evocalcet may not only reduce PTH secretion but also attenuate disease progression in hyperparathyroidism.
Authors
- Yuki Nagata (ORCID: https://orcid.org/0000-0001-9519-3332)
- Keigo Tsushida
- Takehisa Kawata (ORCID: https://orcid.org/0000-0002-1167-6925)
- Waka Haruyama
- Tetsuya Kitayama
- Keisuke Inoue (ORCID: https://orcid.org/0000-0002-8825-1036)
- Masanori Emoto
- Tomoe Hirakawa
- Tetsuo Shoji
- Ikue Kobayashi
- Emi Donoue
- Andrew Arnold
- Masafumi Kurajoh
- Yasuo Imanishi
- Mariko Sakai
Institutions
- University of Connecticut (US)
- Kyowa Kirin (Japan) (JP)
- Osaka City University (JP)
- Osaka Metropolitan University (JP)
- UConn Health (US)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Bone and Mineral Metabolism
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1007/s00774-026-01699-y
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science