Front Cover: Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study (ChemistryOpen 2/2026)
The Front Cover image highlights a computational study of the Ru(II)-catalyzed C–H alkenylation of menadione with ethenesulfonyl fluoride, enabling SuFEx functionalization of quinones. Density functional benchmarking against DLPNO-CCSD(T) establishes a robust mechanistic picture and supports the rational design of naphthoquinone derivatives targeting Trypanosoma cruzi. More details are available in the Research Article by Felipe Fantuzzi and co-workers (DOI: 10.1002/open.202500465).
Authors
- Joyce C. Oliveira
- Renata Almeida
- Cauê Souza
- Esther R. S. Paz (ORCID: https://orcid.org/0000-0001-5489-5100)
- Eufrânio N. da Silva Júnior
- Felipe Fantuzzi
- Chonny Herrera‐Acevedo
- Guilherme A. M. Jardim
- Sulaiman Lakoh
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Sierra Leone (SL)
- University of Kent (GB)
- Escuela Colombiana de Carreras Industriales (CO)
Publication Details
- Journal
- ChemistryOpen
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/open.70155
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00