Regenerative Endodontics in Immature Permanent Teeth: A Comprehensive Review for Pediatric Rehabilitation

<p>Regenerative endodontic procedures (REPs) represent a transformative approach in managing necrotic immature permanent teeth, particularly in pediatric patients. Unlike traditional apexification techniques, REPs focus on biologically based regeneration using stem cells, bioactive scaffolds, and growth factors to restore the pulp–dentin complex. This review explores the evolution, biological foundation, current techniques, scaffold innovations, clinical outcomes, and limitations of REPs, with a focus on their relevance in pediatric dental rehabilitation. Emphasis is placed on the functional and psychosocial benefits of preserving natural tooth structure in children and adolescents. </p>