Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations
Specific mutations in <i>ERG11</i> (F126L, K143R) and <i>FKS1</i> (F621I and hotspot variants) are the primary drivers of the pronounced antifungal resistance observed in Chinese <i>D. catenulata</i> strains, with resistance phenotypes being modulated by nutrient availability.
Authors
- B H He (ORCID: https://orcid.org/0000-0001-6275-4877)
- Na Wang (ORCID: https://orcid.org/0009-0009-5576-9865)
- Meng Xiao (ORCID: https://orcid.org/0000-0003-2103-7008)
- Xi Chen (ORCID: https://orcid.org/0000-0002-8523-3967)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Qi Li
- Ying-Chun Xu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Hebei Provincial Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fcimb.2026.1776442
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- Capital Medical University
- Huazhong University of Science and Technology
- Tongji University
- Peking Union Medical College Hospital
- Peking Union Medical College
- Qingdao University
- Fujian Medical University
- National Key Research and Development Program of China