Effectiveness of Multicomponent Interventions in Slowing Progression of CKD Stages G3-G4
Our findings suggest the potential role of MCIs in delaying CKD progression and improving glycemic control among patients with CKD G3-G4. Nonetheless, the certainty of evidence is low for eGFR and HbA1c and moderate for eGFR slope, suggesting overall modest clinical relevance. High-quality studies are needed to confirm the effectiveness, cost-effectiveness, and scalability of MCIs for this high-risk patient group.
Authors
- Bolu Yang
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Mihir Gandhi (ORCID: https://orcid.org/0000-0002-8902-2710)
- Jie Tan (ORCID: https://orcid.org/0000-0002-0259-9331)
- Sibo Liu (ORCID: https://orcid.org/0009-0007-9850-319X)
- Fahad Javaid Siddiqui
- Chenxinan Ma
- Tazeen H. Jafar
- Lei Wu
Institutions
- National University of Singapore (SG)
- Duke University (US)
- Shanghai Jiao Tong University (CN)
- Singapore General Hospital (SG)
- Wuhan University (CN)
- Duke Institute for Health Innovation (US)
- Duke-NUS Medical School (SG)
- Duke Kunshan University (CN)
- Singapore Clinical Research Institute (SG)
Publication Details
- Journal
- Clinical Journal of the American Society of Nephrology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.2215/cjn.0000000996
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00