Multi‐Level Insights Into Stress Adaptation in <i>Brachypodium distachyon</i>

ABSTRACT Plant growth, development and performance can all be affected by the stimulation of a vast array of physiological, biochemical and metabolic alterations in response to stressors. Plant responses to environmental transitions are highly intricate and depend on several other variables, including the genotype, age and size of the species and the progression rate and persistence of the stress factors. In the face of escalating climate and environmental concerns, greater insight into the underlying stress response mechanisms is crucial to build climate‐resilient agriculture. Owing to its model plant attributes, particularly for monocots, Brachypodium distachyon offers a powerful platform for delving into the molecular basis of biological processes. Besides, its non‐domesticated nature and natural genetic diversity may reveal some of the drivers of environmental adaptation. This review synthesises recent multi‐omics research on Brachypodium 's responses to abiotic and biotic stresses, with a focus on regulatory networks, microbiome interactions, cell wall remodelling and epigenetic stress memory. Thus, knowledge gleaned from Brachypodium research has a strong potential to be exploited for numerous biological processes in agriculturally important crop species.