Dementia with Lewy bodies and additional progressive supranuclear palsy presenting with early postural instability and frequent falls: an autopsy case
This case illustrates that comorbid DLB and PSP can produce an atypical phenotype showing core features of DLB, early severe postural instability, and frequent falls. We believe that dual involvement of tau and α-synuclein pathologies in the mesencephalic locomotor region in the midbrain tegmentum contributed to gait disturbances and falls, leading to cerebral contusion and traumatic subarachnoid hemorrhage.
Authors
- Jun Sone (ORCID: https://orcid.org/0000-0002-9057-7609)
- Naoki Hayashi (ORCID: https://orcid.org/0000-0003-2518-1250)
- Akio Akagi (ORCID: https://orcid.org/0000-0003-4712-7562)
- Hiroaki Miyahara (ORCID: https://orcid.org/0000-0003-0723-0047)
- Hideyuki Moriyoshi (ORCID: https://orcid.org/0000-0002-2737-9669)
- Akiko Yoneyama (ORCID: https://orcid.org/0000-0003-4596-9643)
- Yuichi Riku
- Masahisa Katsuno
- Yasushi Iwasaki
Institutions
- Aichi Medical University (JP)
- Kariya Toyota General Hospital (JP)
- Nagoya University (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1186/s12883-026-04704-z
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00