Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases
Through comprehensive and systematic statistical analysis, we identified the global and local genetic correlations and causal relationships between several intestinal and neurological diseases and discovered shared pleiotropic loci and genes between them. Furthermore, the consistent SNP heritability enrichment observed in immune cells also indicated the crucial role of the immune system in the "gut-brain axis."
Authors
- Qingzhen Fu
- Liwan Wang
- Shiheng Tan
- Zesong Cheng
- Lijing Gao (ORCID: https://orcid.org/0000-0003-2699-0180)
- Tian Tian (ORCID: https://orcid.org/0000-0002-1372-7730)
- Ding Zhang (ORCID: https://orcid.org/0000-0002-0044-5451)
- Zinan Li (ORCID: https://orcid.org/0009-0008-9885-9601)
- Depei Zhang
- Jinyin Liu
- Yanbing Li
- Weiwei Bao
- Fan Wang
- Ning Zhao
- Zhuobo Zhang
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/brb3.71269
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00