Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report

Varicella is usually a mild childhood disease; however, primary infection in adults may lead to severe complications, particularly varicella pneumonia. We report the case of a 32-year-old previously healthy male admitted to the intensive care unit with acute hypoxemic respiratory failure occurring three days after the onset of a diffuse vesicular rash. Chest CT demonstrated bilateral ground-glass opacities with focal consolidation consistent with viral pneumonia. The diagnosis was established based on typical cutaneous findings, epidemiological exposure, and compatible imaging results. Early treatment with intravenous acyclovir followed by oral valacyclovir resulted in favorable clinical and radiological outcomes. This case emphasizes the importance of early recognition and prompt antiviral therapy to improve prognosis, even in immunocompetent adults without classical risk factors.

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Publication Details

Journal
Cureus
Published
2026-02-17
DOI
https://doi.org/10.7759/cureus.103763
Primary Topic
Herpesvirus Infections and Treatments
Type
article
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0.00
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article

Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report

Manal El Goubi, Mohmmed Moussaoui, Khalid K Khaleq
Cureus
Herpesvirus Infections and Treatments
article

Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report

Manal El Goubi, Mohmmed Moussaoui, Khalid K Khaleq
article en

Abstract

Varicella is usually a mild childhood disease; however, primary infection in adults may lead to severe complications, particularly varicella pneumonia. We report the case of a 32-year-old previously healthy male admitted to the intensive care unit with acute hypoxemic respiratory failure occurring three days after the onset of a diffuse vesicular rash. Chest CT demonstrated bilateral ground-glass opacities with focal consolidation consistent with viral pneumonia. The diagnosis was established based on typical cutaneous findings, epidemiological exposure, and compatible imaging results. Early treatment with intravenous acyclovir followed by oral valacyclovir resulted in favorable clinical and radiological outcomes. This case emphasizes the importance of early recognition and prompt antiviral therapy to improve prognosis, even in immunocompetent adults without classical risk factors.

CureusVol. 18(2)
Université Mohammed VI des Sciences et de la Santé (MA), Centre Hospitalier Universitaire Ibn Rochd (MA), Hôpital Universitaire International Cheikh Khalifa (MA)
Good health and well-being
Openalex Percentile: Top 53%
Herpesvirus Infections and Treatments
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Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report — Manal El Goubi, Mohmmed Moussaoui, et al. · Cureus (2026) | TGRS Research Map | TGRS