HPLC‐MS/MS Phenolic Profiling, Antioxidant, Antiaging Activities, and Molecular Docking Studies for <i>Deverra tortuosa</i> and <i>Deverra triradiata</i> Roots and Flowers

Deverra tortuosa and Deverra triradiata are desert perennial shrubs growing extensively in Egypt. We aimed to assess the antioxidant, antiaging, and skin-whitening activities of the aqueous MeOH extract of their roots and flowers, as well as their phenolic content, using HPLC-MS-MS. D. triradiata contained higher phenolic content than D. tortuosa. Phenolic acids and flavonoids account for a significant portion of their extracts. All extracts demonstrated antioxidant activity and inhibited the enzymes elastase, collagenase, and tyrosinase. Compounds 3, 13, 14, and 19 exhibited promising binding to the three enzymes. They displayed the highest affinity to collagenase with binding energies of -9.1, -9.0, -8.4, and -9.2 kcal mol^-1, respectively. In conclusion, the two Deverra species are rich in polyphenols and can be used for controlling free radicals and skin aging-related disorders.