Potential of SP1 as a prognostic marker and therapeutic target in acute myocardial infarction: a bioinformatics, Mendelian randomization and experimental validation study
In this study, by integrating transcriptomic, SMR and PheWAS analysis, we first established a robust causal association between <i>SP1</i> and AMI risk across four cardiovascular tissues, and subsequently delineated a miR-133b/<i>SP1</i>/<i>PLAUR</i> ferroptosis pathway in AMI.
Authors
- Luqiao Wang (ORCID: https://orcid.org/0000-0003-0263-9492)
- Xue Guan
- Zhongyan Li
- Huan Cheng
- Jingru Li
- Najie Wen
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1742618
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00