Successful Cold Atmospheric Plasma as Adjunctive Chronic Wound Therapy: A Case Report and Literature Review

Cold atmospheric plasma, a novel therapeutic modality, has demonstrated promising effects in promoting wound healing through its antimicrobial, inflammation-modulating, and pro-angiogenic properties. However, its clinical application in wound management remains limited. We present the case of a 52-year-old woman with extensive third- to fourth-degree burns, complicated by a chronic postoperative wound secondary to flap necrosis following reconstructive surgery, and persistent infection despite standard wound care and antibiotic therapy. She underwent 2 courses of cold atmospheric plasma treatment, totaling 19 sessions, in conjunction with standard management. The treatment resulted in successful wound healing and eradication of the bacterial infection without adverse effects. This case highlighted the potential of cold atmospheric plasma as a safe and effective adjunctive therapy for chronic, difficult-to-heal wounds with infection, warranting further investigation to establish its role in clinical practice.