First genome sequence and functional profiling of Psychrobacter SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activities
SC65A.3 represents an ancient, ice-adapted Psychrobacter with a dual profile of multidrug resistance and antimicrobial activity, highlighting ice caves as underexplored reservoirs of ancient resistomes and bioactive traits. To our knowledge, this is the first genome analysis of a Psychrobacter isolate from an ice cave and the first characterization of an ancient resistome from this environment, supporting future ecological, biotechnological, and medical exploration.
Authors
- París Lavín (ORCID: https://orcid.org/0000-0002-8893-526X)
- Corina Iţcuş (ORCID: https://orcid.org/0000-0003-2298-8550)
- Victoria Ioana Paun (ORCID: https://orcid.org/0000-0003-4715-0164)
- Cristina Purcărea
- Mariana Carmen Chifiriuc
Institutions
- Universidad de Antofagasta (CL)
- University of Bucharest (RO)
- Academia Oamenilor de Știință din România (RO)
- Romanian Academy (RO)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fmicb.2025.1713017
- Primary Topic
- Polar Research and Ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Româna
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
- Horizon 2020 Framework Programme