Collagen I alleviates UVB-induced oxidative DNA damage and inhibits YAP-p73 apoptotic pathway in human keratinocytes HaCaT
Collagen I-coating protects UVB-irradiated cells from YAP-p73 mediated apoptosis through restricting ROS production and thus alleviating DNA damages, owing to the restored mitophagy. Our study supports the clinical application of collagen products as anti-UVB agents.
Authors
- Shunji HATTORI
- Hitomi Fujisaki (ORCID: https://orcid.org/0000-0002-8119-8543)
- K. Mizuno
- Zhao San
- Toshihiko Hayashi
- Ruiyi Cao
- Yuying Zhu
- Takashi Ikejima
- Tianyu Ji
Institutions
- Shenyang Pharmaceutical University (CN)
- Japan Institute of Leather Research (JP)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1080/03008207.2026.2630869
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00