Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma
In this retrospective analysis of 584 patients who received CAR T-cell therapy for LBCL at six Australian centres we found no association between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.
Authors
- Constantine S. Tam
- Mark R. Dowling (ORCID: https://orcid.org/0000-0002-8056-5348)
- Andrea S. Henden (ORCID: https://orcid.org/0000-0003-2261-169X)
- Anastasia Edelkina (ORCID: https://orcid.org/0000-0002-2836-8291)
- Hamish W Scott (ORCID: https://orcid.org/0009-0005-4953-7815)
- Allison Barraclough (ORCID: https://orcid.org/0000-0003-1615-0540)
- Safia Belbachir
- R. MacDonald
- Catelyn Cashion
- Vinay Vanguru
- Edward R. Scheffer Cliff (ORCID: https://orcid.org/0000-0001-5977-907X)
- Anthony Cole Jeffrey
- Stephen Boyle (ORCID: https://orcid.org/0000-0002-3138-4815)
- Nicole O'Leary (ORCID: https://orcid.org/0009-0000-4338-2246)
- Thomas Buss
- D. Westerman
- Shafqat Inam
- P. Joy Ho
- Emily Blyth
- Michael Dickinson
- Simon J Harrison
- Michelle Wendy Keir
- Jian Li
Institutions
- The University of Sydney (AU)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Royal Brisbane and Women's Hospital (AU)
- Royal Prince Alfred Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Fiona Stanley Hospital (AU)
- The Alfred Hospital (AU)
- Westmead Hospital (AU)
- Monash University (AU)
Publication Details
- Journal
- Blood
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1182/blood.2025032307
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00