Optic neuropathies induced by immune checkpoint inhibitors: A case series and systematic review of the literature
Two distinct patterns of ICI-induced optic neuropathy emerge: papillitis, usually associated with uveitis and Vogt-Koyanagi-Harada syndrome, and optic neuritis, linked to broader immune-related neurological toxicities and poorer outcomes. Our findings suggest that ICIs may be safely reintroduced after full recovery from ICI-related papillitis.
Authors
- Elise Philippakis
- Alberto Vogrig (ORCID: https://orcid.org/0000-0002-3652-7061)
- Emilien Ezine (ORCID: https://orcid.org/0000-0001-5869-1914)
- Giuseppe Aprile (ORCID: https://orcid.org/0000-0003-2007-4077)
- Evelaine Louis
- Renata Ursu
- Stefania Cuzzubbo
- Aude Couturier
- Antoine F. Carpentier
- Céleste Lebbé
Institutions
- University of Udine (IT)
- Inserm (FR)
- Université Paris Cité (FR)
- Saint Louis University Hospital (US)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Lariboisière (FR)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Hôpital Saint-Louis (FR)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1016/j.ejca.2026.116594
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00