Differential modulation of BK channels by simvastatin: Critical role of the auxiliary <i>β</i> 4 subunit

This study identifies BK channel modulation as a novel mechanism underlying simvastatin's neuroprotective effects. β4-containing BK channels are a molecular target of simvastatin in vitro, and their activation profile aligns with simvastatin's anti-seizure effects in vivo. These findings provide a molecular basis for repurposing statins and developing targeted therapies for neurological disorders.