Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency
Ebens et al. demonstrate successful allogeneic hematopoietic cell transplant of CD40L deficiency using an asymptomatic carrier mother donor, with achievement of 32% CD40L expression, recovery of thymopoiesis, normal T cell diversity, and functional outcomes of T and B cell interactions.
Authors
- Christen L. Ebens (ORCID: https://orcid.org/0000-0003-2430-911X)
- Amir A. Sadighi Akha
- Diana Vilkama
- Attila Kumánovics (ORCID: https://orcid.org/0000-0002-4102-3255)
- Tamara C. Pozos (ORCID: https://orcid.org/0000-0003-0763-8763)
- Smitha Hosahalli Vasanna
- Alison Hornyak
Institutions
- Sanford Health (US)
- Mayo Clinic (US)
- Children’s Minnesota - St. Paul Hospital (US)
- Mayo Clinic in Arizona (US)
- Children's Minnesota (US)
- University of Minnesota Medical Center (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2026-02-05
- DOI
- https://doi.org/10.70962/jhi.20250212
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00