Inflammatory and neurotoxic risk of atorvastatin in diabetic peripheral neuropathy: TNF-centered evidence integrating network toxicology, scRNA-Seq, and cell validation
Our findings are consistent with a potential involvement of TNF/TNFα-associated inflammatory responses in atorvastatin-related cellular injury under the tested <i>in vitro</i> conditions. Further TNFα blocking/knockdown experiments will be needed to determine causality.
Authors
- Jingni Wang
- Peilin Zhu
- Jing Chen
- Xin Wang
- Xingchun Wang
- Xingxia Wang
- Hanbing Yang
- Yujun He
- Meng Yuan
- Siyu Mao
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- County Hospital (GB)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fchem.2026.1739085
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong