Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis
This study identifies COL1A1 as a key feature gene associated with EDC-targeted pathways in LUAD. The findings characterize its involvement in ECM-related signaling and its correlation with specific immune cell infiltration patterns, providing a computational framework for understanding EDC-associated molecular changes in LUAD.
Authors
- Tianyu She (ORCID: https://orcid.org/0000-0001-6189-1722)
- Haitao Xu (ORCID: https://orcid.org/0000-0003-1791-547X)
- Xie Zhen
- Fanting Sun
- Yuze Cao
Institutions
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s40360-026-01101-7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00