Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis

This study identifies COL1A1 as a key feature gene associated with EDC-targeted pathways in LUAD. The findings characterize its involvement in ECM-related signaling and its correlation with specific immune cell infiltration patterns, providing a computational framework for understanding EDC-associated molecular changes in LUAD.

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Publication Details

Journal
BMC Pharmacology and Toxicology
Published
2026-02-16
DOI
https://doi.org/10.1186/s40360-026-01101-7
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis

Tianyu She, Haitao Xu, Xie Zhen, Fanting Sun et al.
BMC Pharmacology and Toxicology
Ferroptosis and cancer prognosis
article

Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis

Tianyu She, Haitao Xu, Xie Zhen, Fanting Sun, Yuze Cao
article en

Abstract

This study identifies COL1A1 as a key feature gene associated with EDC-targeted pathways in LUAD. The findings characterize its involvement in ECM-related signaling and its correlation with specific immune cell infiltration patterns, providing a computational framework for understanding EDC-associated molecular changes in LUAD.

BMC Pharmacology and ToxicologyVol. 27(1)
Shandong University of Aeronautics (CN)
Good health and well-being
Openalex Percentile: Top 54%
Ferroptosis and cancer prognosis
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