Ferroptosis-Related Signature Genes and Immune Landscape in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(1) This study is the first to comprehensively demonstrate that decreased FABP4 expression may enhance ferroptosis susceptibility by disrupting lipid metabolism, thereby modulating immune cell recruitment and function in AECOPD.(2) The marked reduction of cDCs suggests that ferroptosis may contribute to dysregulated antigen presentation in AECOPD. Taken together, these findings offer novel mechanistic insights into the interplay between ferroptosis and immune dysfunction in AECOPD and provide a theoretical foundation for the development of targeted diagnostic and therapeutic strategies.