Therapeutic Efficacy and Safety of Recombinant Botulinum Toxin Type A for Moderate to Severe Glabellar Lines: A Randomized, Controlled, Double-blind, Phase III Trial in Chinese Adults

YY001 demonstrated strong efficacy and a favorable safety profile than Botox®. Longer-term and multicenter studies are needed to assess durability, immunogenicity, and applicability across broader populations.

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Publication Details

Journal
Aesthetic Surgery Journal
Published
2026-02-12
DOI
https://doi.org/10.1093/asj/sjag042
Primary Topic
Botulinum Toxin and Related Neurological Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Therapeutic Efficacy and Safety of Recombinant Botulinum Toxin Type A for Moderate to Severe Glabellar Lines: A Randomized, Controlled, Double-blind, Phase III Trial in Chinese Adults

Lai Wei, D. Wu, Lei Li, Jian Sun et al.
Aesthetic Surgery Journal
Botulinum Toxin and Related Neurological Disorders
article

Therapeutic Efficacy and Safety of Recombinant Botulinum Toxin Type A for Moderate to Severe Glabellar Lines: A Randomized, Controlled, Double-blind, Phase III Trial in Chinese Adults

Lai Wei, D. Wu, Lei Li, Jian Sun, Huiping Wang, Jin Chen, Sufan Wu, Baoxi Wang, Jianyun Lu, Hongsen Bi, ShengKang Luo, J Yang, Xiaoli Sun, Nanze Yu, Wu Yang, Xiao Long, Lina Tan, Yan Wu, Xiaoyun Sun, Liming Wu, Songmei Geng
article en

Abstract

YY001 demonstrated strong efficacy and a favorable safety profile than Botox®. Longer-term and multicenter studies are needed to assess durability, immunogenicity, and applicability across broader populations.

Aesthetic Surgery Journal
Central South University (CN), Sun Yat-sen University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Sichuan University (CN), Peking Union Medical College Hospital (CN), Tianjin Medical University General Hospital (CN), West China Hospital of Sichuan University (CN), Nanfang Hospital (CN), Wuhan Union Hospital (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Peking University First Hospital (CN), Zhejiang Provincial People's Hospital (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Peking University Third Hospital (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN), Beijing Tsinghua Chang Gung Hospital (CN), Guangdong Provincial People's Hospital (CN), Third Xiangya Hospital (CN), Union Hospital (CN), Chongqing Medical and Pharmaceutical College (CN), Chongqing Medical University (CN)
Openalex Percentile: Top 57%
Botulinum Toxin and Related Neurological Disorders
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