The <i>ARRplus</i> : a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronism
Renin-dependent and sex-specific aldosterone cut-offs using the <i>ARRplus</i> offer higher diagnostic accuracy than the ARR and considerably reduced rates of false-positives to minimize follow-up of screened patients, particularly women.
Authors
- Hanna Remde (ORCID: https://orcid.org/0000-0002-3499-5910)
- Jacques W.M. Lenders (ORCID: https://orcid.org/0000-0002-7658-4466)
- Manuel Schulze (ORCID: https://orcid.org/0009-0008-5819-0835)
- Sybille Fuld (ORCID: https://orcid.org/0009-0000-8560-9920)
- Mirko Peitzsch (ORCID: https://orcid.org/0000-0002-2472-675X)
- Tracy Ann Williams (ORCID: https://orcid.org/0000-0002-2388-6444)
- George Mangos (ORCID: https://orcid.org/0000-0001-5700-5417)
- Carmina Teresa Fuß (ORCID: https://orcid.org/0000-0002-1466-5287)
- Graeme Eisenhofer (ORCID: https://orcid.org/0000-0002-8601-9903)
- Lydia Kürzinger
- Georgiana Constantinescu (ORCID: https://orcid.org/0000-0002-7304-2557)
- Sven Gruber (ORCID: https://orcid.org/0000-0003-0601-4334)
- Francesco Alessi
- Isabella Sudano
- Denise Brüdgam
- Felix Beuschlein
- Martin Reincke
- Jun Yang
- Christina Pamporaki
Institutions
- Radboud University Nijmegen (NL)
- University of Zurich (CH)
- Hudson Institute of Medical Research (AU)
- Radboud University Medical Center (NL)
- University Hospital of Zurich (CH)
- St George Hospital (AU)
- Universitätsklinikum Würzburg (DE)
- Center for Systems Biology Dresden (DE)
- University Hospital Carl Gustav Carus (DE)
- Monash University (AU)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1515/cclm-2025-1670
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00