Argon plasma-activated liquid inactivates Helicobacter pylori and resistant hospital pathogens through acidification and reactive species
PAL generated with an argon plasma electrosurgical source exhibits potent antibacterial activity, driven by low pH and RONS dynamics. PAL effectively inactivates MDR pathogens and other clinically relevant pathogens, including <i>H. pylori</i>. The stomach's acidic environment may enhance PAL activity by maintaining the low-pH conditions required for pH-dependent reactive nitrogen chemistry associated with antibacterial efficacy.
Authors
- Alexander Neugebauer (ORCID: https://orcid.org/0000-0002-3254-2168)
- Ulrich Biber (ORCID: https://orcid.org/0000-0001-9788-1761)
- Markus D. Enderle (ORCID: https://orcid.org/0000-0002-4001-025X)
- C. C. Thompson (ORCID: https://orcid.org/0000-0002-0358-6452)
- Jan Liese (ORCID: https://orcid.org/0000-0003-1717-3517)
- Leander Heisterberg
- Sebastian M. Grashorn
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Institute of Medical Microbiology and Hygiene (DE)
- Erbe Elektromedizin (Germany) (DE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fmicb.2026.1771100
- Primary Topic
- Plasma Applications and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00