Intermittent fasting ameliorates MAFLD by downregulating Lrg1: insights from bulk RNA sequencing and functional verification
Transcriptome analysis elucidated the potential mechanism by which intermittent fasting improves MAFLD, highlighting the important role of fatty acid metabolism and inflammatory responses. Several key genes regulating MAFLD through IF were identified. Knocking down the key gene Lrg1 inhibited the expression of lipogenic genes and effectively slowed MAFLD progression.
Authors
- Hua Liang (ORCID: https://orcid.org/0000-0001-5512-8595)
- H Chen
- Wenqiang Xie
- Jie Shen
- Shilin Zhang
Institutions
- The First People's Hospital of Shunde (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fendo.2026.1754251
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00