GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activity in the middle cerebral artery occlusion (MCAO) model
These results suggest that the neuroprotective effects of GW201 are mediated by its ability to allosterically modulate NMDA receptor activity, reducing calcium overload, influence downstream gene expression and suppress inflammatory responses.
Authors
- Jin Zengliang
- Liu Jingjing
- Liu Qi
- Wang Shen
- Murezati Tiliwaerde
- Ji Hongxian
- Dong Zhaoji
- Gu Wei
- Gao Huan
Institutions
- Xinjiang Medical University (CN)
- Capital Medical University (CN)
- National Institutes of Pharmaceutical Research and Development (China) (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1111/bph.70359
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China