Exploring the role of TWIST1 in malocclusion and craniofacial morphology
This study identifies a putative functional noncoding variant that dysregulates <i>TWIST1</i> via disruption of <i>PITX2</i> DNA binding and links this effect to postnatal craniofacial phenotypes in both humans and mice. These findings expand the developmental and genetic framework for understanding malocclusion and suggest a broader role for <i>TWIST1</i> in cranial base growth and midface patterning.
Authors
- Aline Lourenço Petrin (ORCID: https://orcid.org/0000-0003-2239-8120)
- Brad A. Amendt (ORCID: https://orcid.org/0000-0001-6524-1006)
- Steven Eliason
- Lina M. Moreno Uribe
- Clarissa S. G. Da Fontoura
Institutions
- University of Iowa (US)
- American Association of Endodontists (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fphys.2026.1749243
- Primary Topic
- Craniofacial Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research
- National Center for Advancing Translational Sciences