Pachymic acid targets PDIA6 to delay mesenchymal stem cell senescence through the G6PD/STAT3 signaling axis and prevent senile osteoporosis
These findings elucidate that PA specifically targets PDIA6, alleviating PDIA6-mediated inhibition of G6PD and activating the G6PD/STAT3 signaling axis to counteract hMSC senescence. PA ameliorates SOP by delaying BMSC senescence through this conserved mechanism.
Authors
- Jinyan Xu (ORCID: https://orcid.org/0000-0003-4265-7150)
- Wenting Chen (ORCID: https://orcid.org/0000-0003-4230-1189)
- Yi Luo
- Ru-Ming Liu
- Ruixin Zhang
- Jian-Hui Xiao
- Yan Xu
- Yong-Sheng Liu
- Xin-Xin Zhu
- Xu YANG
- Huan Yuan
Institutions
- Zunyi Medical University (CN)
- Institute of Mechanics (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.02.009
- Citations
- 1
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 41.22