<i>BRAF</i> V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice
This is the first fully penetrant mouse model of BRAF-driven GIST by inducing BRAFV600E in c-Kit+ ICC. This model faithfully recapitulates human BRAF-mutant GIST, enabling mechanistic studies and preclinical testing of targeted therapies, including response to BRAF inhibition with dabrafenib.
Authors
- Robert Koogle
- John Glod (ORCID: https://orcid.org/0000-0002-3071-7876)
- Lino Tessarollo (ORCID: https://orcid.org/0000-0001-6420-772X)
- Colleen Barrick
- Sudhirkumar Yanpallewar (ORCID: https://orcid.org/0000-0001-5929-4822)
- B. Widemann
- Elijah F. Edmondson (ORCID: https://orcid.org/0000-0002-6106-3705)
- Dieter Saur (ORCID: https://orcid.org/0000-0001-5874-0210)
- Francesco Tomassoni-Ardori
- Karlyne M. Reilly
Institutions
- Leidos (United States) (US)
- TUM Klinikum (DE)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Research Network (United States) (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0725
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00