A Cyclic Pentapeptide Inhibits AgrC as a Quorum-Sensing Quenching Agent in Staphylococcus aureus
These findings identify a promising cyclic pentapeptide inhibitor of AgrC that effectively attenuates <i>S. aureus</i> virulence without exerting bactericidal pressure. This work provides a valuable lead compound and offers novel insights for the development of advanced, safe, and effective antivirulence therapeutics.
Authors
- Duiyuan Ai (ORCID: https://orcid.org/0000-0003-1479-5361)
- Huanhuan Duan
- Jiahao Yao
Institutions
- Gansu Agricultural University (CN)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-02-15
- DOI
- https://doi.org/10.3390/antibiotics15020213
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00