Age‐ and alcohol‐related differences in adolescent neurometabolite levels

In a sample of moderate-to-heavy drinking adolescents, findings suggest associations between age and neurometabolites in dACC neurometabolites, which potentially reflect ongoing neuronal maturation, myelination, and shifts in excitatory and inhibitory neurotransmission. Lower tNAA among recent heavier drinkers may reflect associations between alcohol exposure and neuronal damage. Broader neurometabolic effects may emerge only with heavier or prolonged alcohol use.