Pulsed Radiofrequency and Epigenetic Modulation of Pain Pathways: A Systematic Review Based on Preclinical Evidence
Preclinical data support a non-destructive PRF mechanism involving dampening of neuro-immune signaling and restoration of inhibitory tone. Direct epigenetic evidence remains limited (single study) and absent in humans. Priorities include standardized PRF parameter reporting, time-course and multi-omic profiling beyond <i>Kcc2</i>, and prospective clinical studies incorporating molecular endpoints and circulating epigenetic readouts.
Authors
- Jacopo Mosca
- R. Gazzeri
- Giuliano Lo Bianco (ORCID: https://orcid.org/0000-0003-2705-1548)
- Fabrizio Micheli
- Christopher Robinson
Institutions
- Johns Hopkins University (US)
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- Johns Hopkins Medicine (US)
- Policlinico Umberto I (IT)
- Fondazione Istituto G. Giglio di Cefalù (IT)
- Guglielmo da Saliceto Hospital (IT)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jpr.s582117
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00