Visceral and Subcutaneous Fat Deposits Exhibit Distinct Roles in the Initiation and Progression of Breast Cancer
This study reveals a paradoxical role of adipose tissue in breast cancer, as it may promote tumorigenesis yet confer a post-mastectomy survival advantage. Body composition's prognostic complexity necessitates targeted therapies targeting fat-muscle crosstalk in cancer management.
Authors
- Wei-Wei Niu
- Yu Xing (ORCID: https://orcid.org/0000-0001-8075-9612)
- Chunwei Li (ORCID: https://orcid.org/0000-0001-6628-7698)
- Kang Yu
- Yu Zhang
- Fu-Quan Zhang
- Yi Pang
- Lin Li
- Yu-Chen Fan
- Li Zhao
- Yu Liu
- Yuan-Yuan Bao
- Qi Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Tianjin Third Central Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Breast Cancer Targets and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/bctt.s565061
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation