Multi-omics SMR and experimental supportive analyses decipher causal drivers hepatocellular carcinoma
By integrating germline (GWAS-based) and somatic evidence, this study provides a comprehensive view of HCC pathogenesis. This integrated strategy successfully identified a core set of genes and proteins with potential causal links to HCC, elucidating their functional convergence in cancer biology. These findings offer novel molecular insights and candidate targets for precise diagnosis, prognostic assessment, and targeted therapy of HCC, laying a solid foundation for future translational research.
Authors
- Zhaochen Ma
- Jiarui Yu (ORCID: https://orcid.org/0000-0002-7309-156X)
- Zhiya Yang
- T. Li
- Chao Lei (ORCID: https://orcid.org/0000-0003-4509-2001)
- Yao Huang (ORCID: https://orcid.org/0009-0007-3303-7968)
- Jiayun Shen
- Ying Li
- Ming Zhang
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s12885-026-15667-2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00