QUADAS-3 Explanation and Elaboration: Guidance for Quality Assessment of Diagnostic Test Accuracy Studies
This article explains how to use the QUADAS-3 tool. The article guides the reviewer through the initial stages of defining the questions and conceptualizing the ideal test accuracy trial, how the domains and signaling questions should be interpreted and assessed, and how judgments of risk of bias and concerns regarding applicability should be made. Authors of systematic reviews of diagnostic test accuracy studies should use this article as a guide for applying the QUADAS-3 tool.
Authors
- J. Holmes
- Anne WS Rutjes (ORCID: https://orcid.org/0000-0001-9782-779X)
- Clare Davenport
- Christopher Hyde (ORCID: https://orcid.org/0000-0002-7349-0616)
- Yemisi Takwoingi (ORCID: https://orcid.org/0000-0002-5828-9746)
- Patrick M M Bossuyt
- Penny Whiting
- Eve Tomlinson
- Sue Mallett
- Mariska M.G. Leeflang
- Jonathan J. Deeks
- Johannes B. Reitsma
- Marie E. Westwood
- Bada Yang
Institutions
- University of Exeter (GB)
- University Medical Center Utrecht (NL)
- University of Bristol (GB)
- Saint Camillus International University of Health and Medical Sciences (IT)
- NIHR Exeter Clinical Research Facility (GB)
- UCL Biomedical Research Centre (GB)
- Amsterdam University Medical Centers (NL)
- NIHR Birmingham Biomedical Research Centre (GB)
- University College London (GB)
Publication Details
- Journal
- Annals of Internal Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.7326/annals-25-04943
- Citations
- 1
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 28.09