Population Pharmacokinetic Modeling and Target Attainment of Cefepime in Critically Ill Pediatric Patients

Given the variability observed in critically ill children, clinicians should consider incorporating therapeutic drug monitoring and popPK models to determine optimal dosing in this population. The use of extended infusions and more frequent or continuous dosing is beneficial for PK/PD target achievement, particularly for <i>Pseudomonas aeruginosa</i> and antimicrobial-resistant pathogens. Use of these strategies should be strongly considered in the pediatric critically ill population.