Interaction of genetic and lifestyle risk scores on colorectal cancer risk across 5 racial and ethnic populations
Our study suggests that lifestyle modification may offer greater risk reduction among those at higher genetic risk. Future research is warranted to enhance the integration of genetics and lifestyle in CRC risk stratification and screening approaches across populations.
Authors
- Tanya L. Alderete (ORCID: https://orcid.org/0000-0002-7751-9543)
- Trang VoPham (ORCID: https://orcid.org/0000-0003-4787-1201)
- Sihao Han (ORCID: https://orcid.org/0000-0003-3433-3068)
- D. O. Stram
- David Bogumil (ORCID: https://orcid.org/0000-0002-5001-1088)
- Louise Wang (ORCID: https://orcid.org/0000-0002-9261-8371)
- P. C. Wan
- H. J. Lenz
- Kimberly D. Siegmund
- Adelynn Paik
- Lynne R. Wilkens
- Ulrike Peters
- Xin Sheng
- Christopher A Haiman
- Fei Chen
- Loïc Le Marchand
- Bodour Salhia
- Brian Z Huang
- David V Conti
Institutions
- University of Southern California (US)
- Johns Hopkins University (US)
- Hawaii Pacific University (US)
- University of Washington (US)
- Keck Hospital of USC (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- Fred Hutch Cancer Center (US)
- Cancer Center of Hawaii (US)
- USC Norris Comprehensive Cancer Center (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1093/jnci/djag045
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00